HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ABL2 (P42684)
Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
Gene: ABL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH3_1~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0007173 - epidermal growth factor receptor signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 380
Hs

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Last updated: 15 Jul 2024