HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: LIMS1 (P48059)
LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)
Gene: LIMS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	10022929, 9843575, 10574708, 15721255
Identification Methods	pull down, two hybrid, enzyme linked immunosorbent assay, nuclear magnetic resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 325
+	Hs
		209008 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		557639 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		782755 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		200163 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		TGFI1_HUMAN (193-316): 1.71e-33: 130: 31.45
+	Hs
		412085 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		442793 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Mm
		403454 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		PAXI_MOUSE (190-318): 1.34e-39: 148: 37.98
+	Hs
		823358 BLK_HUMAN (7-204): 3.35e-19: 91: 19.80		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		411641 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		823365 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		522857 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		PAXI_HUMAN (190-318): 4.32e-39: 147: 37.98
+	Hs
		924889 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PDLI7_HUMAN (191-324): 1.12e-35: 135: 29.85
+	Hs
		111447 J3QRU1_HUMAN (6-120): 6.72e-16: 81.2: 23.08		PDLI7_HUMAN (191-324): 1.12e-35: 135: 29.85
+	Hs
		442845 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		FHL5_HUMAN (6-188): 2.42e-28: 112: 27.13
+	Hs
		782788 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		FHL2_HUMAN (217-325): 3.32e-13: 70.4: 27.03
+	Hs
		150552 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		ABLM1_HUMAN (3-146): 5.18e-26: 110: 22.92
+	Hs
		300996 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		ABLM3_HUMAN (179-323): 3.04e-25: 108: 22.97
+	Hs
		442827 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		FHL2_HUMAN (217-325): 3.32e-13: 70.4: 27.03
+	Ce
		107567 SRC2_CAEEL (1-202): 6.89e-21: 96: 16.75		G5EFG1_CAEEL (191-302): 1.15e-12: 70.5: 33.33
+	Hs
		254384 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		LDB3_HUMAN (2-64): 8.39e-15: 76.9: 25.40