HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: EFNB2 (P52799)
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)
Gene: EFNB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.570

Property	Details
Experiments	15764601, 12606549
Identification Methods	nuclear magnetic resonance, circular dichroism
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 333
+	Mm
		223008 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		EFNB2_MOUSE (4-333): 0: 510: 96.97
+	Hs
		209030 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23
+	Mm
		223007 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		EFNB1_MOUSE (9-333): 6.5e-164: 462: 54.23
+	Xl
		140380 Q6V1R3_XENLA (1-380): 2.29e-96: 293: 82.68		EFNB1_XENLA (24-333): 2.49e-147: 419: 58.86
+	Hs
		655281 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		EFNB2_HUMAN (1-333): 0: 517: 100.00
+	Hs
		129251 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		EFNB2_HUMAN (1-333): 0: 517: 100.00
+	Hs
		411651 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		EFNB2_HUMAN (1-333): 0: 517: 100.00
+	Hs
		129276 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23
+	Hs
		522911 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		EFNB1_HUMAN (9-333): 2.72e-167: 471: 54.23
+	Hs
		522869 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		EFNA5_HUMAN (15-204): 1.2e-55: 182: 23.15