HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: HNRPK (P61978)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Gene: HNRNPK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	16189514, 11557983
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 463
+	Mm
		223009 NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05		HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00
+	Hs
		782763 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		904174 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		412116 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		442807 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		903956 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Mm
		904258 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00
+	Hs
		903873 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Rn
		904380 GRB2_RAT (3-61): 2.24e-18: 84.7: 28.81		HNRPK_RAT (1-463): 1.31e-129: 385: 100.00
+	Hs
		904074 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Hs
		522880 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00
+	Mm
		643095 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		PCBP2_MOUSE (23-147): 1.3e-12: 70.9: 21.09
+	Hs
		655435 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		655379 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15
+	Hs
		789115 FRK_HUMAN (3-132): 2.88e-18: 88.3: 18.71		PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15
+	Hs
		924755 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29
+	Hs
		924788 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		FUBP3_HUMAN (331-457): 1.39e-11: 68.5: 24.41
+	Hs
		522876 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		PCBP3_HUMAN (2-114): 1.36e-12: 70.9: 16.24
+	Hs
		522998 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		PCBP2_HUMAN (23-131): 1.39e-12: 70.9: 23.21
+	Hs
		924908 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		IF2B1_HUMAN (175-462): 1.88e-09: 62: 11.57