HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	23602568
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 688
+	Hs
		209147 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22
+	Hs
		522902 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66
+	Hs
		411675 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		CDK3_HUMAN (378-688): 7.03e-93: 292: 17.41
+	Hs
		655279 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6A3_HUMAN (2-362): 2.51e-78: 266: 13.83
+	Hs
		412095 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A3_HUMAN (2-362): 2.51e-78: 266: 13.83
+	Hs
		655378 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	Hs
		412203 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	Hs
		129296 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	Hs
		412205 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A1_HUMAN (2-359): 1.19e-76: 262: 14.13
+	Hs
		789116 FRK_HUMAN (3-132): 2.88e-18: 88.3: 18.71		KS6A1_HUMAN (2-359): 1.19e-76: 262: 14.13
+	Hs
		522867 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		KS6A3_HUMAN (2-362): 2.51e-78: 266: 13.83
+	Hs
		433360 YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	Hs
		270416 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52
+	Hs
		834094 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11
+	Hs
		272890 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		KS6A4_HUMAN (3-378): 1.53e-33: 139: 16.17
+	Hs
		433348 YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08		KCC2G_HUMAN (376-686): 1.18e-29: 126: 16.51