HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	22745667
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035591 - signaling adaptor activity GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 443
+	Mm
		1141333 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		557667 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		782780 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991902 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Rn
		1144374 P85A_RAT (163-379): 8.5e-24: 105: 16.14		KHDR1_RAT (1-443): 0: 515: 94.36
+	Mm
		763394 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		655330 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		454827 FGR_HUMAN (7-155): 1.02e-23: 104: 18.54		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		403437 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		412149 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		442815 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Mm
		1141126 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		KHDR1_MOUSE (1-443): 0: 514: 94.36
+	Hs
		991778 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		411689 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		789110 FRK_HUMAN (3-132): 2.88e-18: 88.3: 18.71		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		924509 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		991842 SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35		KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00
+	Hs
		209060 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		SF01_HUMAN (82-301): 6.63e-54: 192: 21.33
+	Mm
		763412 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65
+	Mm
		1141173 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65