HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10026169
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1, PH~SH3_9, RhoGEF~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007173 - epidermal growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1333
+	Hs
		557668 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		557669 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		992496 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992475 GRAP_HUMAN (5-169): 7.3e-28: 110: 15.74		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		655332 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		412150 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		442816 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992521 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		655333 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		412151 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		557683 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		557756 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RPGF5_HUMAN (522-1018): 7.32e-85: 291: 16.12
+	Hs
		655361 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		412185 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		442826 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		557709 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RGPS1_HUMAN (774-945): 3.81e-23: 107: 31.43
+	Hs
		548645 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		411981 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		224699 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85
+	Hs
		279897 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83