HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.769

Property	Details
Experiments	22057045, 16337946
Identification Methods	pull down, anti tag coimmunoprecipitation, two hybrid
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 913
+	Hs
		557671 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DDR1_HUMAN (1-913): 0: 911: 100.00
+	Hs
		208983 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		208993 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		209065 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		557606 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		557707 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Rn
		71362 B2RZ33_RAT (1-379): 7.98e-91: 279: 68.50		NTRK2_RAT (604-906): 6.67e-105: 345: 43.89
+	Hs
		209063 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		557705 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		384213 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		522833 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Rn
		88904 D4A3M8_RAT (1-380): 3.21e-98: 298: 95.79		INSR_RAT (600-908): 1.98e-51: 198: 36.25
+	Hs
		435526 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		557661 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26
+	Mm
		337637 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		ABL1_MOUSE (604-903): 6.09e-49: 190: 37.67
+	Dm
		448247 NCK_DROME (6-377): 1.75e-68: 226: 39.90		INSR_DROME (616-912): 1.91e-52: 202: 38.03
+	Hs
		411329 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		435570 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		782751 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		FRK_HUMAN (607-912): 8.14e-50: 186: 36.04