HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	26871637, 25416956, 32296183, unassigned1304
Identification Methods	two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 533
+	Hs
		557674 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		1141384 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		209129 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		557750 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		203208 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		655347 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		412165 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		442821 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		1141385 GRAP_MOUSE (5-169): 2.87e-26: 106: 17.13		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		763395 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		655407 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		782795 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		782797 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Mm
		763411 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		536209 FGR_MOUSE (6-155): 1.85e-22: 100: 18.42		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		782828 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		655419 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		203228 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		655524 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Hs
		412433 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90