HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 839
+	Hs
		557705 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		209065 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		557707 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Rn
		71362 B2RZ33_RAT (1-379): 7.98e-91: 279: 68.50		NTRK2_RAT (6-839): 0: 557: 52.88
+	Hs
		384213 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		208983 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		208993 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		557606 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		208976 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		434130 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		209040 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Rn
		88904 D4A3M8_RAT (1-380): 3.21e-98: 298: 95.79		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		557671 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		557661 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Ce
		105201 CSK1_CAEEL (148-379): 2.74e-32: 129: 19.36		EGL15_CAEEL (220-831): 5.8e-120: 389: 24.66
+	Hs
		435526 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		557826 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		411329 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435570 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16