HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: PKN2 (Q16513)
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Gene: PKN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	10026169, 16752908
Identification Methods	affinity chromatography technology, nuclear magnetic resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 984
+	Hs
		557706 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		PKN2_HUMAN (1-984): 0: 1145: 97.99
+	Hs
		655279 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6A3_HUMAN (442-929): 3.75e-111: 362: 22.16
+	Hs
		412095 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A3_HUMAN (442-929): 3.75e-111: 362: 22.16
+	Hs
		412145 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KPCD_HUMAN (653-980): 1.78e-96: 321: 47.42
+	Hs
		655378 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00
+	Hs
		412203 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00
+	Hs
		129296 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		KS6A2_HUMAN (569-965): 2.87e-89: 303: 25.00
+	Hs
		412205 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KS6A1_HUMAN (571-920): 1.64e-86: 295: 27.52
+	Hs
		616675 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6B1_HUMAN (397-670): 1.04e-27: 120: 12.04
+	Hs
		681710 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Mm
		643056 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		AKT1_MOUSE (397-605): 1.55e-17: 88.6: 11.16
+	Hs
		655233 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Hs
		129308 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		PKN3_HUMAN (12-215): 6.12e-17: 88.2: 20.69
+	Hs
		412046 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Mm
		643082 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		KPCT_MOUSE (397-560): 1.76e-14: 79.7: 13.33
+	Mm
		554895 P70304_MOUSE (166-379): 5.35e-24: 105: 16.36		KPCE_MOUSE (397-485): 2.05e-14: 79.7: 14.61
+	Hs
		412141 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KPCT_HUMAN (397-567): 7.7e-15: 80.9: 13.37
+	Mm
		403418 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		AKT1_MOUSE (397-605): 1.55e-17: 88.6: 11.16
+	Mm
		403411 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		KPCE_MOUSE (397-485): 2.05e-14: 79.7: 14.61
+	Mm
		411915 LCK_MOUSE (3-188): 2.6e-19: 91.4: 16.58		KPCE_MOUSE (397-485): 2.05e-14: 79.7: 14.61