HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	12074588
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0014069 - postsynaptic density
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 822
+	Hs
		557707 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK2_HUMAN (1-822): 0: 638: 100.00
+	Rn
		71362 B2RZ33_RAT (1-379): 7.98e-91: 279: 68.50		NTRK2_RAT (1-822): 0: 622: 93.55
+	Hs
		209063 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		208993 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		557705 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		557606 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		208983 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		384213 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507832 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		208996 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		557644 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		EPHB1_HUMAN (149-822): 1.29e-142: 447: 23.00
+	Hs
		208976 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		434130 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		209040 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Rn
		88904 D4A3M8_RAT (1-380): 3.21e-98: 298: 95.79		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		557671 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		435526 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		557661 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		557826 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Dm
		448247 NCK_DROME (6-377): 1.75e-68: 226: 39.90		INSR_DROME (513-808): 9.56e-64: 235: 41.10