HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: CYFP1 (Q7L576)
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)
Gene: CYFIP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030032 - lamellipodium assembly
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 1253
+	Hs
		209138 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		557725 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		557769 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Mm
		643101 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		CYFP1_MOUSE (1-1253): 0: 2079: 99.04
+	Hs
		523037 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		433396 YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08		CYFP1_HUMAN (1-1253): 0: 2086: 100.00
+	Hs
		924782 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		523107 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Hs
		433444 YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08		CYFP2_HUMAN (1-1253): 0: 2070: 85.92
+	Dm
		993203 GRAP_DROME (204-368): 9.19e-17: 80.1: 30.72		CYFIP_DROME (1-1253): 0: 1903: 65.73