HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: Q86TF7 (Q86TF7)
Homeobox C4
Gene: HOXC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 264
+	Hs
		208978 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		HXC4_HUMAN (1-264): 3.26e-55: 180: 99.62
+	Hs
		209009 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		HXA1_HUMAN (10-229): 1.28e-32: 123: 29.65
+	Hs
		208985 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		HXD8_HUMAN (12-231): 3.3e-31: 118: 25.00
+	Hs
		557620 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		HXC8_HUMAN (8-224): 1.47e-34: 126: 23.50
+	Hs
		557634 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		NKX21_HUMAN (1-250): 2.55e-30: 118: 16.80
+	Hs
		412045 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		HXC8_HUMAN (8-224): 1.47e-34: 126: 23.50
+	Hs
		655270 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		HXA1_HUMAN (10-229): 1.28e-32: 123: 29.65
+	Hs
		411952 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		HXB5_HUMAN (27-231): 2.28e-33: 123: 38.65
+	Hs
		412077 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		NKX21_HUMAN (1-250): 2.55e-30: 118: 16.80
+	Hs
		678897 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		HXC8_HUMAN (8-224): 1.47e-34: 126: 23.50
+	Hs
		522809 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		HXC8_HUMAN (8-224): 1.47e-34: 126: 23.50
+	Hs
		447219 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		HXB5_HUMAN (27-231): 2.28e-33: 123: 38.65
+	Hs
		433220 YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08		HXB5_HUMAN (27-231): 2.28e-33: 123: 38.65
+	Hs
		799074 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		NKX21_HUMAN (1-250): 2.55e-30: 118: 16.80
+	Hs
		522846 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		NKX21_HUMAN (1-250): 2.55e-30: 118: 16.80