HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	32640226, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0014069 - postsynaptic density
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1332
+	Hs
		557740 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		209186 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		557820 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		411790 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		208968 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324734 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Mm
		956970 NCK1_MOUSE (1-379): 6.79e-91: 279: 68.24		M4K4_MOUSE (1-1332): 0: 993: 56.32
+	Hs
		324717 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324782 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		557731 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Dm
		1182596 NCK_DROME (6-377): 1.75e-68: 226: 39.90		Q7KV88_DROME (3-770): 1.46e-122: 410: 42.14
+	Ce
		1095301 Q95PW9_CAEEL (1-379): 5.2e-75: 239: 37.88		MIG15_CAEEL (5-738): 2.65e-112: 381: 38.26
+	Hs
		557840 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		411778 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		655388 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		M3K11_HUMAN (26-779): 1.45e-120: 397: 21.38
+	Hs
		1217590 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		412163 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99
+	Hs
		924683 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		412425 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		442897 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60