HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: WIPF2 (Q8TF74)
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)
Gene: WIPF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	12213210, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 440
+	Hs
		209112 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		557748 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		WIPF2_HUMAN (1-440): 4.28e-32: 128: 100.00
+	Hs
		166030 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		557740 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		209071 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		TGO1_HUMAN (104-359): 3.95e-21: 98.8: 22.71
+	Hs
		62638 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		62640 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		203208 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Ce
		712432 Q95PW9_CAEEL (1-379): 5.2e-75: 239: 37.88		SC161_CAEEL (125-438): 4.92e-18: 89.1: 15.90
+	Hs
		1257321 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		WIPF2_HUMAN (1-440): 4.28e-32: 128: 100.00
+	Hs
		166056 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166032 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166024 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		166049 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		SYNJ2_HUMAN (6-410): 2.46e-30: 126: 12.59
+	Hs
		62648 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		62646 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		WIPF3_HUMAN (24-435): 4.61e-21: 97.2: 29.33
+	Hs
		203228 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		203198 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		SYNJ1_HUMAN (103-438): 2.34e-18: 90.3: 17.19
+	Hs
		655524 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		MYO16_HUMAN (3-288): 2.53e-10: 64.9: 14.00
+	Hs
		412433 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		MYO16_HUMAN (3-288): 2.53e-10: 64.9: 14.00