HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: TRI41 (Q8WV44)
E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41)
Gene: TRIM41

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 630
+	Hs
		557799 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		TRI39_HUMAN (133-630): 1.99e-142: 425: 31.09
+	Hs
		209157 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		TRI15_HUMAN (136-628): 6.8e-105: 327: 26.69
+	Hs
		412363 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		TRI39_HUMAN (133-630): 1.99e-142: 425: 31.09
+	Hs
		924879 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		TRI39_HUMAN (133-630): 1.99e-142: 425: 31.09
+	Hs
		523137 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		TRI15_HUMAN (136-628): 6.8e-105: 327: 26.69
+	Hs
		208986 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		TRI27_HUMAN (7-127): 8.35e-20: 95.1: 18.80
+	Hs
		655400 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		TRI72_HUMAN (175-619): 5.37e-32: 131: 28.07
+	Hs
		584954 GRAP_HUMAN (5-169): 7.3e-28: 110: 15.74		RO52_HUMAN (7-141): 1.35e-20: 97.4: 21.53
+	Hs
		411977 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		TRI27_HUMAN (7-127): 8.35e-20: 95.1: 18.80
+	Hs
		442773 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		TRI27_HUMAN (7-127): 8.35e-20: 95.1: 18.80
+	Hs
		1078906 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		TRIM5_HUMAN (6-150): 3.22e-22: 102: 19.46
+	Hs
		433465 YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08		TRIM5_HUMAN (6-150): 3.22e-22: 102: 19.46
+	Hs
		536781 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		TRI27_HUMAN (7-127): 8.35e-20: 95.1: 18.80
+	Hs
		411890 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		TRI35_HUMAN (3-147): 4.52e-17: 86.6: 16.55
+	Hs
		523048 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		TRI50_HUMAN (10-134): 7.23e-18: 88.9: 16.92
+	Hs
		523138 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		TRIM7_HUMAN (15-144): 2.04e-15: 81.2: 17.36