HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32640226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 833
+	Hs
		557762 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		557840 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Hs
		557731 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Hs
		655434 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		412291 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		1217590 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Hs
		412425 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Ce
		1095301 Q95PW9_CAEEL (1-379): 5.2e-75: 239: 37.88		MIG15_CAEEL (11-415): 1.01e-110: 365: 35.00
+	Hs
		209186 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		TNIK_HUMAN (11-296): 3.35e-64: 236: 42.57
+	Hs
		209112 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58
+	Hs
		681710 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		557820 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		TNIK_HUMAN (11-296): 3.35e-64: 236: 42.57
+	Hs
		454830 FGR_HUMAN (7-155): 1.02e-23: 104: 18.54		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		557740 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58
+	Hs
		282266 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		CDKL5_HUMAN (12-589): 4.98e-125: 400: 18.62
+	Mm
		643056 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		AKT1_MOUSE (1-337): 5.84e-129: 396: 23.12
+	Hs
		655233 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		412046 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		412163 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		STK4_HUMAN (4-437): 2.54e-121: 376: 33.10
+	Dm
		1182596 NCK_DROME (6-377): 1.75e-68: 226: 39.90		Q7KV88_DROME (11-340): 1.96e-68: 248: 41.31