HitPredict

Interactor 1: PLRG1 (O43660)
Pleiotropic regulator 1
Gene: PLRG1

Interactor 2: RUXF (P62306)
Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)
Gene: SNRPF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 514 Hs			1 86
+	Hs
		209501 PLRG1_HUMAN (1-514): 1.02e-144: 427: 100.00		LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40
+	Hs
		1377166 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00
+	Hs
		1288409 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00
+	Hs
		911927 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00
+	Hs
		903646 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00
+	Hs
		903090 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00
+	Hs
		1288404 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40
+	Hs
		912701 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22
+	Sc
		795437 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		SMD3_YEAST (1-76): 1.44e-26: 95: 25.00
+	Sc
		873682 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		RUXF_YEAST (4-77): 6.37e-26: 93: 56.00
+	Hs
		903627 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40
+	Hs
		903093 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22
+	Hs
		912695 FBXW7_HUMAN (315-514): 1.35e-42: 163: 21.78		SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22
+	Hs
		197113 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00
+	Hs
		196988 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00
+	Hs
		196991 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		LSM6_HUMAN (3-77): 1.23e-30: 104: 45.33
+	Hs
		197110 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40
+	Hs
		196993 PRP4_HUMAN (200-398): 1.15e-15: 81.6: 26.87		SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22