HitPredict

Interactor 1: PLRG1 (O43660)
Pleiotropic regulator 1
Gene: PLRG1

Interactor 2: SYF1 (Q9HCS7)
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)
Gene: XAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000974 - Prp19 complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 514 Hs			1 855
+	Hs
		1288323 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		SYF1_HUMAN (1-855): 0: 602: 100.00
+	Sp
		142003 PRP46_SCHPO (10-439): 2.04e-69: 231: 19.27		SYF1_SCHPO (21-772): 2.32e-148: 457: 43.65
+	Hs
		209476 PLRG1_HUMAN (1-514): 1.02e-144: 427: 100.00		CRNL1_HUMAN (166-822): 5.62e-47: 182: 14.51
+	Sc
		978489 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		SYF1_YEAST (19-733): 1.86e-87: 298: 22.31
+	Dm
		54179 Q9VYQ9_DROME (2-514): 3.35e-113: 345: 56.81		SYF1_DROME (1-255): 9.35e-16: 83.9: 13.69
+	Hs
		175177 TBL1R_HUMAN (191-514): 2.22e-85: 274: 19.20		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Hs
		1288293 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		CRNL1_HUMAN (166-822): 5.62e-47: 182: 14.51
+	Hs
		175317 FBW1A_HUMAN (180-441): 1.45e-69: 235: 25.73		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Sp
		141996 PRP46_SCHPO (10-439): 2.04e-69: 231: 19.27		CLF1_SCHPO (471-778): 7.87e-33: 137: 13.61
+	Hs
		1022304 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		CSTF3_HUMAN (11-543): 2.99e-35: 145: 13.25
+	Hs
		174768 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		OGT1_HUMAN (7-468): 1.59e-37: 154: 13.55
+	Sp
		224207 TUP11_SCHPO (229-514): 1.67e-77: 256: 19.33		CYC8_SCHPO (3-232): 7.02e-13: 74.7: 10.26
+	Hs
		300229 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		PRP6_HUMAN (2-353): 4.69e-26: 117: 12.92
+	Hs
		903236 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		SART3_HUMAN (18-578): 1.7e-31: 134: 12.80
+	Sp
		224208 TUP12_SCHPO (237-512): 1.12e-71: 240: 21.88		CYC8_SCHPO (3-232): 7.02e-13: 74.7: 10.26
+	Hs
		1058048 NLE1_HUMAN (49-357): 5.8e-65: 220: 17.74		RRP5_HUMAN (11-347): 9.5e-18: 90.8: 11.26
+	Hs
		300095 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		PRP6_HUMAN (2-353): 4.69e-26: 117: 12.92
+	Hs
		1058000 SNR40_HUMAN (26-356): 1.15e-62: 210: 17.51		RRP5_HUMAN (11-347): 9.5e-18: 90.8: 11.26
+	Hs
		903230 WDR5_HUMAN (20-315): 8.55e-56: 191: 13.06		RRP5_HUMAN (11-347): 9.5e-18: 90.8: 11.26
+	Sc
		1015445 PRP46_YEAST (146-439): 1.87e-55: 193: 20.59		CLF1_YEAST (3-250): 5.35e-11: 68.5: 12.06