HitPredict

Interactor 1: LDB2 (O43679)
LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)
Gene: LDB2

Interactor 2: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Hs			1 158
+	Hs
		210834 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60
+	Mm
		223255 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL2_MOUSE (12-148): 2.2e-41: 143: 32.61
+	Hs
		210830 LDB2_HUMAN (1-373): 0: 677: 100.00		ISL1_HUMAN (22-148): 6.29e-41: 141: 34.38
+	Mm
		223246 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL1_MOUSE (22-148): 6.29e-41: 141: 34.38
+	Mm
		223243 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN2_MOUSE (1-158): 3.35e-41: 137: 99.37
+	Hs
		210831 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO4_HUMAN (11-147): 3.1e-39: 132: 42.34
+	Hs
		210838 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO3_HUMAN (30-156): 5.7e-39: 130: 58.27
+	Mm
		223252 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO3_MOUSE (30-156): 5.7e-39: 130: 58.27
+	Hs
		210827 LDB2_HUMAN (1-373): 0: 677: 100.00		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Mm
		223248 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO4_MOUSE (11-147): 4.66e-38: 129: 42.34
+	Mm
		223254 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN1_MOUSE (11-150): 3.96e-38: 128: 52.86
+	Mm
		223263 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX2_MOUSE (94-152): 2.22e-11: 62.3: 25.42
+	Hs
		210841 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX4_HUMAN (89-155): 5.05e-11: 61.5: 26.87
+	Mm
		223245 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX4_MOUSE (89-155): 5e-11: 61.5: 26.87
+	Mm
		223247 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX5_MOUSE (93-155): 6.58e-11: 61.1: 19.05
+	Mm
		223262 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX9_MOUSE (94-152): 1.46e-10: 60: 27.12
+	Mm
		223249 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX1_MOUSE (93-155): 1.92e-10: 59.6: 19.05
+	Mm
		223242 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1B_MOUSE (94-155): 6.97e-10: 58: 27.42
+	Mm
		223259 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1A_MOUSE (89-155): 1.17e-09: 57.3: 16.42
+	Hs
		238112 LDB1_HUMAN (8-373): 0: 610: 76.84		LMX1B_HUMAN (94-155): 6.75e-10: 58: 27.42