HitPredict

Interactor 1: LDB2 (O43679)
LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1)
Gene: LDB2

Interactor 2: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	18330356
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 373 Hs			1 390
+	Mm
		223245 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX4_MOUSE (1-390): 8.46e-108: 323: 98.97
+	Mm
		223259 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1A_MOUSE (2-347): 1.01e-67: 220: 27.37
+	Mm
		223247 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX5_MOUSE (29-388): 1.31e-64: 213: 32.93
+	Mm
		223249 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX1_MOUSE (29-389): 3.38e-61: 204: 32.13
+	Mm
		223242 LDB2_MOUSE (1-373): 0: 677: 97.59		LMX1B_MOUSE (10-347): 3.61e-60: 201: 28.27
+	Hs
		210830 LDB2_HUMAN (1-373): 0: 677: 100.00		ISL1_HUMAN (20-321): 6.12e-51: 175: 27.57
+	Mm
		223246 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL1_MOUSE (20-321): 6.12e-51: 175: 27.57
+	Hs
		210834 LDB2_HUMAN (1-373): 0: 677: 100.00		LHX8_HUMAN (24-290): 3.3e-50: 174: 29.90
+	Hs
		210838 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO3_HUMAN (19-158): 3.93e-52: 172: 37.67
+	Mm
		223252 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO3_MOUSE (19-158): 3.93e-52: 172: 37.67
+	Mm
		223255 LDB2_MOUSE (1-373): 0: 677: 97.59		ISL2_MOUSE (21-319): 4.35e-47: 166: 27.73
+	Mm
		223263 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX2_MOUSE (8-361): 1.02e-46: 166: 22.25
+	Mm
		223262 LDB2_MOUSE (1-373): 0: 677: 97.59		LHX9_MOUSE (19-357): 1.39e-43: 157: 23.03
+	Hs
		238112 LDB1_HUMAN (8-373): 0: 610: 76.84		LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00
+	Hs
		822644 LDB1_HUMAN (8-373): 0: 610: 76.84		LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13
+	Hs
		210831 LDB2_HUMAN (1-373): 0: 677: 100.00		LMO4_HUMAN (29-150): 2.22e-31: 118: 43.31
+	Mm
		223248 LDB2_MOUSE (1-373): 0: 677: 97.59		LMO4_MOUSE (29-150): 2.22e-31: 118: 43.31
+	Hs
		210827 LDB2_HUMAN (1-373): 0: 677: 100.00		RBTN1_HUMAN (89-189): 8.78e-11: 61.9: 16.83
+	Mm
		223254 LDB2_MOUSE (1-373): 0: 677: 97.59		RBTN1_MOUSE (89-189): 9.04e-11: 61.9: 16.83
+	Hs
		638528 LDB1_HUMAN (8-373): 0: 610: 76.84		RBTN1_HUMAN (89-189): 8.78e-11: 61.9: 16.83