Interactor 1: BUB1 (O43683)
Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)
Gene: BUB1

Interactor 2: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 26186194, 26496610, 28514442, 33961781, 25416956, 26148513, 36736316, 16760428, 20220147, 21988832
Identification Methods affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Mad3_BUB1_I~WD40
Common GO terms GO:0000776 - kinetochore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007094 - mitotic spindle assembly checkpoint signaling
GO:0051301 - cell division
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 1085
Hs

1 328
+ Hs
+ Hs
+ Hs
+ Ce
+ Dm
+ Sc
+ Hs
+ At
+ Dm
+ Sp
+ Hs
+ Sc
+ Hs

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Last updated: 15 Jul 2024