HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	25833949, 26438829, 31365120, 32867711, 35217622
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043130 - ubiquitin binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 328 Hs			1 2799
+	Hs
		304289 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		304102 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		UBR5_HUMAN (1-2799): 0: 3949: 100.00
+	Hs
		125026 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94
+	Hs
		211207 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Hs
		267800 TAF5L_HUMAN (17-146): 4.7e-09: 59.3: 36.23		HECW2_HUMAN (2170-2798): 1.03e-139: 482: 19.72
+	Hs
		1192155 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27
+	Hs
		125310 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94
+	Hs
		903156 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93