HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24981860, 33022573
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 328 Hs			1 334
+	Hs
		903551 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903418 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		792949 LIS1_HUMAN (168-319): 3.74e-31: 122: 14.47		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903428 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		943844 RAE1L_HUMAN (3-326): 2.75e-99: 299: 33.63		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Hs
		943879 RAE1L_HUMAN (3-326): 2.75e-99: 299: 33.63		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Hs
		211260 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54
+	Mm
		925836 LIS1_MOUSE (168-319): 3.02e-31: 123: 14.47		LIS1_MOUSE (2-289): 1.02e-94: 288: 29.49
+	Hs
		792935 LIS1_HUMAN (168-319): 3.74e-31: 122: 14.47		LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49
+	Hs
		209467 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Sp
		999838 TUP11_SCHPO (1-213): 6.22e-64: 214: 17.90		TUP11_SCHPO (3-117): 1.07e-31: 126: 25.19
+	Sp
		999842 TUP11_SCHPO (1-213): 6.22e-64: 214: 17.90		TUP12_SCHPO (2-118): 1.15e-30: 123: 20.30
+	Hs
		1103007 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Hs
		1346954 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		NLE1_HUMAN (197-332): 1.05e-32: 128: 22.54
+	Hs
		1281292 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15
+	Ca
		483033 TUP1_CANAL (1-206): 8.77e-55: 188: 17.18		TUP1_CANAL (3-118): 7.12e-20: 92: 19.38
+	Hs
		1240442 POC1B_HUMAN (134-327): 7.29e-41: 150: 13.93		POC1A_HUMAN (10-75): 1.3e-13: 73.1: 22.73
+	Hs
		1074780 TAF5_HUMAN (65-295): 2.05e-24: 105: 18.35		TAF5_HUMAN (163-330): 6.22e-12: 68.6: 25.25
+	Hs
		197071 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39