HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 328 Hs			1 4911
+	Mm
		903669 WDR5_MOUSE (209-320): 6.93e-20: 90.4: 16.07		KMT2C_MOUSE (1-4911): 0: 2324: 84.57
+	Hs
		211190 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		165604 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		1080207 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		EZH2_HUMAN (4563-4893): 4.31e-83: 294: 20.99
+	Hs
		211161 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		211283 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	Dm
		113998 Q9W1T0_DROME (2-315): 6.17e-99: 296: 26.32		M9PB30_DROME (3022-3853): 1.79e-13: 80.4: 10.32
+	Hs
		331862 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		211281 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152559 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		1288292 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Hs
		1059779 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		1018714 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		975303 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		165657 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		975304 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		1018633 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		152678 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		1288387 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152622 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82