HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: KMT2B (Q9UMN6)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 328 Hs			1 2715
+	Hs
		1288387 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		KMT2B_HUMAN (1-2715): 0: 1040: 100.00
+	Hs
		903604 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		KMT2B_HUMAN (1-2715): 0: 1040: 100.00
+	Hs
		211283 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		SET1B_HUMAN (1961-2715): 3.45e-66: 252: 23.84
+	Hs
		211190 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		211161 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		1080207 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		165604 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		SET1A_HUMAN (2571-2715): 1.52e-26: 122: 52.74
+	Dm
		113998 Q9W1T0_DROME (2-315): 6.17e-99: 296: 26.32		M9PB30_DROME (1874-2434): 4.3e-17: 91.3: 12.94
+	Hs
		975303 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		152559 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		KMT2D_HUMAN (396-778): 9.23e-10: 67.2: 20.80
+	Hs
		211213 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		KMT2C_HUMAN (2005-2475): 4.5e-09: 64.8: 11.39
+	Hs
		903609 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		SET1B_HUMAN (1961-2715): 3.45e-66: 252: 23.84
+	Hs
		975304 SNR40_HUMAN (1-121): 1.07e-23: 101: 17.42		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		903149 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		1219301 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		PHF6_HUMAN (1573-1755): 1.92e-32: 133: 19.12
+	Hs
		152678 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		KMT2D_HUMAN (396-778): 9.23e-10: 67.2: 20.80
+	Hs
		165657 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		SET1A_HUMAN (2571-2715): 1.52e-26: 122: 52.74
+	Hs
		152622 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		KMT2D_HUMAN (396-778): 9.23e-10: 67.2: 20.80
+	Hs
		903374 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		KMT2C_HUMAN (2005-2475): 4.5e-09: 64.8: 11.39
+	Mm
		903669 WDR5_MOUSE (209-320): 6.93e-20: 90.4: 16.07		KMT2C_MOUSE (1780-2314): 8.79e-09: 63.6: 14.34