HitPredict

Interactor 1: SIGL6 (O43699)
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
Gene: SIGLEC6

Interactor 2: TLR5 (O60602)
Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Gene: TLR5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, LRR_8~ig, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 453 Hs			1 858
+	Hs
		211424 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25
+	Hs
		1344389 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25
+	Hs
		120114 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19
+	Hs
		211423 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR9_HUMAN (233-587): 6.35e-21: 100: 18.29
+	Hs
		179919 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR3_HUMAN (2-322): 1.33e-15: 83.3: 15.66
+	Hs
		211422 SIGL6_HUMAN (1-453): 1.09e-99: 307: 100.00		TLR10_HUMAN (262-662): 1.04e-14: 80.6: 13.22
+	Hs
		237442 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57
+	Hs
		120187 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19
+	Hs
		1344383 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR9_HUMAN (233-587): 6.35e-21: 100: 18.29
+	Hs
		120185 SIGL7_HUMAN (23-453): 3.93e-74: 241: 50.11		TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19
+	Hs
		1348546 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR7_HUMAN (196-561): 2.98e-20: 98.7: 18.11
+	Hs
		237523 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR2_HUMAN (3-499): 3.23e-17: 88.7: 14.47
+	Hs
		179970 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR3_HUMAN (2-322): 1.33e-15: 83.3: 15.66
+	Mm
		885977 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR8_MOUSE (208-574): 3.44e-17: 88.7: 15.44
+	Hs
		1315643 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR10_HUMAN (262-662): 1.04e-14: 80.6: 13.22
+	Hs
		1073338 SIGL9_HUMAN (33-453): 3.87e-76: 247: 49.89		TLR1_HUMAN (249-574): 3.69e-12: 72.2: 13.67
+	Mm
		1162019 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR1_MOUSE (2-168): 1.18e-13: 77.2: 15.12
+	Mm
		1265201 SIG12_MOUSE (28-453): 2.65e-74: 242: 44.12		TLR4_MOUSE (182-684): 2.6e-12: 72.9: 16.14
+	Mm
		1162020 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR4_MOUSE (182-684): 2.6e-12: 72.9: 16.14
+	Mm
		1162021 Q6PJ50_MOUSE (31-453): 9.65e-74: 241: 44.19		TLR2_MOUSE (455-720): 8.22e-10: 64.5: 16.30