Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4
Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.79 | 1.00 | 0.893 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, 26320552, unassigned2173 |
| Identification Methods | two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CH~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005178 - integrin binding GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane and 8 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
