HitPredict

Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: MAGI1 (Q96QZ7)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)
Gene: MAGI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12042308
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030054 - cell junction GO:0042995 - cell projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 911 Hs			1 1491
+	Hs
		521598 ACTN1_HUMAN (20-911): 0: 607: 85.76		MAGI1_HUMAN (1-1491): 0: 756: 100.00
+	Mm
		49891 A1BN54_MOUSE (20-911): 0: 593: 84.08		DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61
+	Hs
		521581 ACTN1_HUMAN (20-911): 0: 607: 85.76		LNX1_HUMAN (13-376): 2.39e-12: 74.1: 11.92
+	Hs
		521540 ACTN1_HUMAN (20-911): 0: 607: 85.76		SCRIB_HUMAN (838-1232): 4.22e-09: 63.5: 23.26
+	Mm
		885081 ACTN4_MOUSE (1-911): 0: 574: 97.70		DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61
+	Hs
		211617 ACTN4_HUMAN (1-911): 0: 586: 100.00		LNX1_HUMAN (13-376): 2.39e-12: 74.1: 11.92
+	Hs
		211579 ACTN4_HUMAN (1-911): 0: 586: 100.00		SCRIB_HUMAN (838-1232): 4.22e-09: 63.5: 23.26
+	Hs
		725643 ACTN2_HUMAN (19-911): 0: 556: 77.16		DLG4_HUMAN (14-112): 3.09e-17: 89.9: 19.23
+	Mm
		1267826 ACTN2_MOUSE (19-911): 0: 558: 77.49		GRIP1_MOUSE (12-585): 6.4e-16: 86: 10.86
+	Hs
		993277 ACTN3_HUMAN (37-911): 0: 567: 74.51		LNX1_HUMAN (13-376): 2.39e-12: 74.1: 11.92
+	Hs
		725649 ACTN2_HUMAN (19-911): 0: 556: 77.16		DLG1_HUMAN (14-110): 1.24e-15: 84.8: 19.61
+	Ce
		86403 Q23158_CAEEL (1-907): 4.54e-168: 515: 59.25		C1P633_CAEEL (16-555): 6.2e-28: 124: 13.64
+	Hs
		993251 ACTN3_HUMAN (37-911): 0: 567: 74.51		SCRIB_HUMAN (838-1232): 4.22e-09: 63.5: 23.26
+	Hs
		725654 ACTN2_HUMAN (19-911): 0: 556: 77.16		SCRIB_HUMAN (838-1232): 4.22e-09: 63.5: 23.26
+	Ce
		105581 Q9XVU8_CAEEL (1-907): 7.44e-175: 531: 61.34		DLG1_CAEEL (14-590): 1.11e-09: 65.2: 9.26
+	Ce
		88177 H2L2C8_CAEEL (85-907): 3.05e-154: 476: 61.41		D3YT29_CAEEL (16-555): 3.57e-25: 115: 13.64
+	Ce
		105571 Q23158_CAEEL (1-907): 4.54e-168: 515: 59.25		DLG1_CAEEL (14-590): 1.11e-09: 65.2: 9.26
+	Mm
		1143324 SPTB2_MOUSE (285-829): 1.98e-09: 63.9: 11.15		DLG4_MOUSE (14-110): 4.36e-17: 89.1: 19.61
+	Dm
		1182589 Q7KV70_DROME (486-754): 8.13e-09: 62: 14.39		KIBRA_DROME (301-428): 1.81e-13: 77.8: 33.33
+	Dm
		1182586 Q7KV70_DROME (486-754): 8.13e-09: 62: 14.39		PATJ_DROME (13-306): 9.56e-12: 71.9: 12.69