HitPredict

Interactor 1: TLX3 (O43711)
T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)
Gene: TLX3

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	20211142, 35140242, 19250647
Identification Methods	two hybrid, proximity labelling technology, pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 291 Hs			1 770
+	Hs
		211840 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		679096 TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Mm
		526710 MSX1_MOUSE (46-242): 2.45e-45: 156: 26.70		TLE4_MOUSE (1-770): 0: 563: 86.27
+	Hs
		211839 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		679098 TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		679097 TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		678903 HXC8_HUMAN (52-229): 4.66e-35: 128: 23.46		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		211838 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Hs
		658626 MSX1_HUMAN (46-242): 8.37e-50: 168: 29.13		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Hs
		211844 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Mm
		526708 MSX1_MOUSE (46-242): 2.45e-45: 156: 26.70		TLE5_MOUSE (1-200): 1.04e-91: 287: 64.50
+	Hs
		679101 TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		678908 HXC8_HUMAN (52-229): 4.66e-35: 128: 23.46		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		211960 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		TBL1R_HUMAN (558-769): 4.54e-47: 177: 15.65
+	Hs
		211773 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Mm
		223203 TLX3_MOUSE (1-291): 6.02e-54: 179: 99.66		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Hs
		211820 TLX3_HUMAN (1-291): 5.64e-54: 179: 100.00		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		245566 TLX1_HUMAN (2-290): 2.68e-37: 136: 54.30		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Mm
		678773 HXA2_MOUSE (50-235): 3.31e-35: 131: 25.13		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Hs
		245638 NANOG_HUMAN (102-281): 1.1e-34: 129: 29.47		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51