HitPredict

Interactor 1: ITM2A (O43736)
Integral membrane protein 2A (Protein E25)
Gene: ITM2A

Interactor 2: ATP7B (P35670)
Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]
Gene: ATP7B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 1465
+	Rn
		1140238 ITM2B_RAT (1-261): 5.33e-142: 400: 40.45		AT2B4_RAT (617-1453): 0: 584: 17.33
+	Rn
		513727 ITM2B_RAT (1-261): 5.33e-142: 400: 40.45		AT2A2_RAT (711-1399): 0: 572: 16.79
+	Hs
		619300 ITM2B_HUMAN (1-261): 3.52e-138: 390: 40.08		AT2B4_HUMAN (617-1453): 0: 582: 17.03
+	Rn
		1140240 ITM2B_RAT (1-261): 5.33e-142: 400: 40.45		AT2B3_RAT (617-1450): 6.31e-178: 567: 16.14
+	Rn
		416173 ITM2B_RAT (1-261): 5.33e-142: 400: 40.45		AT1A3_RAT (720-1410): 3.24e-178: 560: 16.54
+	Rn
		1140241 ITM2B_RAT (1-261): 5.33e-142: 400: 40.45		AT2A1_RAT (711-1428): 5.72e-177: 556: 16.55
+	Rn
		416154 ITM2B_RAT (1-261): 5.33e-142: 400: 40.45		AT1A1_RAT (719-1411): 1.15e-176: 556: 16.38
+	Hs
		531005 ITM2B_HUMAN (1-261): 3.52e-138: 390: 40.08		AT1A3_HUMAN (720-1410): 2.11e-178: 561: 16.42
+	Hs
		164040 ITM2B_HUMAN (1-261): 3.52e-138: 390: 40.08		AT2A1_HUMAN (711-1445): 4.62e-177: 557: 16.13
+	Hs
		212286 ITM2A_HUMAN (1-263): 1.34e-142: 402: 100.00		ATP7A_HUMAN (557-636): 5.32e-10: 66.4: 28.75