HitPredict

Interactor 1: CYH3 (O43739)
Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)
Gene: CYTH3

Interactor 2: ICEF1 (Q8WWN9)
Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)
Gene: IPCEF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	32296183, 28514442, 12920129, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~PH, PH~Sec7
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 437
+	Hs
		1074107 CYH1_HUMAN (1-400): 4.59e-176: 498: 84.25		ICEF1_HUMAN (1-437): 6.24e-102: 312: 100.00
+	Hs
		1262771 CYH2_HUMAN (3-400): 2.9e-174: 493: 80.91		ICEF1_HUMAN (1-437): 6.24e-102: 312: 100.00
+	Hs
		1262772 CYH4_HUMAN (13-400): 1.81e-167: 476: 72.94		ICEF1_HUMAN (1-437): 6.24e-102: 312: 100.00
+	Mm
		1194493 CYH1_MOUSE (1-400): 6.77e-177: 500: 83.00		CNKR2_MOUSE (11-432): 8.75e-84: 279: 32.25
+	Mm
		926282 CYH2_MOUSE (3-400): 1.82e-173: 491: 80.40		CNKR2_MOUSE (11-432): 8.75e-84: 279: 32.25
+	Mm
		140106 CYH3_MOUSE (1-400): 1.01e-170: 484: 98.75		CNKR2_MOUSE (11-432): 8.75e-84: 279: 32.25
+	Hs
		1074109 CYH1_HUMAN (1-400): 4.59e-176: 498: 84.25		CNKR1_HUMAN (9-321): 7.89e-36: 142: 24.17
+	Hs
		1281529 CYH2_HUMAN (3-400): 2.9e-174: 493: 80.91		CNKR1_HUMAN (9-321): 7.89e-36: 142: 24.17
+	Hs
		212319 CYH3_HUMAN (12-400): 6.36e-172: 487: 100.00		CNKR1_HUMAN (9-321): 7.89e-36: 142: 24.17
+	Hs
		212313 CYH1_HUMAN (1-400): 4.59e-176: 498: 84.25		CYH3_HUMAN (18-143): 4.39e-31: 125: 14.29
+	Hs
		1281534 CYH4_HUMAN (13-400): 1.81e-167: 476: 72.94		CNKR1_HUMAN (9-321): 7.89e-36: 142: 24.17
+	Hs
		1074113 CYH1_HUMAN (1-400): 4.59e-176: 498: 84.25		CYH2_HUMAN (42-143): 2.63e-25: 108: 19.51
+	Dm
		1181488 Q9V9Q6_DROME (7-399): 1.69e-159: 456: 63.87		Q7KNQ9_DROME (22-258): 9.78e-38: 148: 25.00
+	Dm
		1360475 Q9V9Q6_DROME (7-399): 1.69e-159: 456: 63.87		Q9V9Q6_DROME (42-143): 1.55e-32: 129: 18.03
+	Mm
		1194484 IQEC1_MOUSE (48-369): 3.9e-94: 304: 26.93		CNKR2_MOUSE (11-432): 8.75e-84: 279: 32.25
+	Hs
		1150560 IQEC1_HUMAN (48-369): 7.86e-95: 306: 26.93		PKHA4_HUMAN (16-415): 3.4e-42: 160: 17.20
+	Hs
		1331765 BIG1_HUMAN (9-273): 2.71e-92: 305: 39.19		PKHA4_HUMAN (16-415): 3.4e-42: 160: 17.20
+	Hs
		1266554 GBF1_HUMAN (7-307): 1.43e-89: 297: 29.72		PKHA4_HUMAN (16-415): 3.4e-42: 160: 17.20