HitPredict

Interactor 1: AAKB2 (O43741)
5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
Gene: PRKAB2

Interactor 2: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 25416956, 25852190, 31900314, 35271311, 32707033, 36736316, 20562859, 16306228, 21988832, 23455922, 28514442, 33961781, 24722188, 22363791
Identification Methods two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AMPK1_CBM~AdenylateSensor, AMPK1_CBM~Pkinase, AMPKBI~AdenylateSensor, AMPKBI~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006633 - fatty acid biosynthetic process
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 272
Hs

1 559
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Ce
+ Ce
+ At
+ At
+ At
+ At
+ Sp
+ At
+ At
+ Zm
+ At
+ Sc
+ Sc
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024