HitPredict

Interactor 1: CHP2 (O43745)
Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520)
Gene: CHP2

Interactor 2: SL9A1 (P19634)
Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
Gene: SLC9A1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	12576672, 33961781, 16710297, 31912575
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, fluorescence technology, microscale thermophoresis, isothermal titration calorimetry, anti tag coimmunoprecipitation, biophysical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	EF-hand_7~NEXCaM_BD
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070886 - positive regulation of calcineurin-NFAT signaling cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 815
+	Hs
		586063 CHP1_HUMAN (1-195): 1.03e-45: 151: 61.03		SL9A1_HUMAN (1-815): 0: 823: 100.00
+	Hs
		586058 CHP3_HUMAN (12-195): 5.63e-45: 149: 25.85		SL9A1_HUMAN (1-815): 0: 823: 100.00
+	Rn
		642813 CHP2_RAT (1-196): 3.21e-46: 152: 81.63		SL9A1_RAT (1-815): 0: 787: 93.17
+	Rn
		642812 CHP1_RAT (1-195): 1.54e-45: 150: 60.51		SL9A1_RAT (1-815): 0: 787: 93.17
+	Rn
		822755 CHP2_RAT (1-196): 3.21e-46: 152: 81.63		SL9A2_RAT (34-799): 0: 686: 46.38
+	Rn
		822754 CHP1_RAT (1-195): 1.54e-45: 150: 60.51		SL9A2_RAT (34-799): 0: 686: 46.38
+	Hs
		212574 CHP2_HUMAN (1-196): 5.76e-49: 159: 100.00		SL9A2_HUMAN (85-799): 0: 660: 47.00
+	Hs
		1305458 CHP1_HUMAN (1-195): 1.03e-45: 151: 61.03		SL9A2_HUMAN (85-799): 0: 660: 47.00
+	Hs
		212565 CHP2_HUMAN (1-196): 5.76e-49: 159: 100.00		SL9A3_HUMAN (81-806): 0: 622: 39.03
+	Hs
		822764 CHP1_HUMAN (1-195): 1.03e-45: 151: 61.03		SL9A3_HUMAN (81-806): 0: 622: 39.03
+	Rn
		642816 CHP2_RAT (1-196): 3.21e-46: 152: 81.63		SL9A3_RAT (76-806): 0: 614: 37.99
+	Rn
		642815 CHP1_RAT (1-195): 1.54e-45: 150: 60.51		SL9A3_RAT (76-806): 0: 614: 37.99
+	Hs
		212570 CHP2_HUMAN (1-196): 5.76e-49: 159: 100.00		SL9A4_HUMAN (54-697): 0: 568: 44.92
+	Rn
		642819 CHP2_RAT (1-196): 3.21e-46: 152: 81.63		SL9A4_RAT (54-697): 0: 570: 44.63
+	Rn
		642818 CHP1_RAT (1-195): 1.54e-45: 150: 60.51		SL9A4_RAT (54-697): 0: 570: 44.63
+	Hs
		1149580 CHP1_HUMAN (1-195): 1.03e-45: 151: 61.03		SL9A4_HUMAN (54-697): 0: 568: 44.92
+	Hs
		212568 CHP2_HUMAN (1-196): 5.76e-49: 159: 100.00		SL9A5_HUMAN (75-713): 7.33e-172: 520: 40.30
+	Rn
		1194995 CHP2_RAT (1-196): 3.21e-46: 152: 81.63		SL9A5_RAT (57-715): 9.51e-172: 520: 39.27
+	Hs
		1060400 CHP1_HUMAN (1-195): 1.03e-45: 151: 61.03		SL9A5_HUMAN (75-713): 7.33e-172: 520: 40.30
+	Rn
		895408 CHP1_RAT (1-195): 1.54e-45: 150: 60.51		SL9A5_RAT (57-715): 9.51e-172: 520: 39.27