HitPredict

Interactor 1: AP1G1 (O43747)
AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)
Gene: AP1G1

Interactor 2: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Adaptin_N, Alpha_adaptinC2~Alpha_adaptinC2, Alpha_adaptinC2~B2-adapt-app_C
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016020 - membrane GO:0016192 - vesicle-mediated transport GO:0048488 - synaptic vesicle endocytosis and 1 others more... GO:0098793 - presynapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 937
+	Hs
		212624 AP1G1_HUMAN (1-822): 0: 833: 100.00		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		276363 AP1G2_HUMAN (6-822): 0: 690: 58.02		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		276366 AP1G2_HUMAN (6-822): 0: 690: 58.02		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Mm
		567513 AP2A1_MOUSE (3-808): 0: 595: 25.00		AP2B1_MOUSE (1-937): 0: 926: 99.89
+	Hs
		321523 AP2A1_HUMAN (3-808): 0: 594: 24.39		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		302132 AP2A2_HUMAN (3-813): 0: 582: 24.55		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		321535 AP2A1_HUMAN (3-808): 0: 594: 24.39		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		302144 AP2A2_HUMAN (3-813): 0: 582: 24.55		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Dm
		954826 AP2A_DROME (3-807): 0: 562: 22.73		Q24253_DROME (1-937): 0: 804: 71.75
+	At
		1228260 AP2A1_ARATH (1-804): 0: 553: 24.53		APBLB_ARATH (3-936): 0: 750: 56.14
+	Hs
		302075 AP2A1_HUMAN (3-808): 0: 594: 24.39		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	At
		286690 APBLC_ARATH (30-812): 0: 556: 16.42		AP2A1_ARATH (13-934): 0: 556: 16.10
+	At
		1228256 AP2A1_ARATH (1-804): 0: 553: 24.53		AP2A1_ARATH (13-934): 0: 556: 16.10
+	Hs
		1357660 AP4E1_HUMAN (5-746): 0: 557: 23.08		AP4B1_HUMAN (15-628): 3.34e-176: 530: 29.63