HitPredict

Interactor 1: STX6 (O43752)
Syntaxin-6
Gene: STX6

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	30833792, 35271311, 26186194, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~SNARE
Common GO terms	GO:0000149 - SNARE binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0019905 - syntaxin binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 295
+	Hs
		212995 STX6_HUMAN (1-239): 4.31e-68: 212: 100.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		235158 STX10_HUMAN (1-239): 5.84e-67: 209: 61.09		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Dm
		1095557 Q5BI25_DROME (13-255): 4.37e-54: 180: 38.41		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Zm
		39691 A0A1D6N0J7_MAIZE (2-254): 2.02e-65: 206: 27.31		A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80
+	Hs
		873597 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		169421 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		169605 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		212982 STX6_HUMAN (1-239): 4.31e-68: 212: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		235208 STX10_HUMAN (1-239): 5.84e-67: 209: 61.09		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1095586 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		873588 BET1L_HUMAN (155-253): 9.93e-19: 80.7: 19.00		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Dm
		1095587 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Sc
		696591 TLG1_YEAST (2-238): 4.64e-31: 116: 16.46		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		1306217 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		169588 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1353750 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366628 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		1353751 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366629 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53