HitPredict

Interactor 1: STX6 (O43752)
Syntaxin-6
Gene: STX6

Interactor 2: VPS45 (Q9NRW7)
Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)
Gene: VPS45

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 34079125, 33961781, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Sec1
Common GO terms	GO:0000139 - Golgi membrane GO:0005794 - Golgi apparatus GO:0006886 - intracellular protein transport
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 570
+	Hs
		235214 STX10_HUMAN (1-239): 5.84e-67: 209: 61.09		VPS45_HUMAN (1-570): 0: 647: 100.00
+	Hs
		1345175 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		VPS45_HUMAN (1-570): 0: 647: 100.00
+	Hs
		169625 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		VPS45_HUMAN (1-570): 0: 647: 100.00
+	Hs
		212953 STX6_HUMAN (1-239): 4.31e-68: 212: 100.00		SCFD1_HUMAN (18-553): 2.28e-141: 425: 20.10
+	Hs
		235200 STX10_HUMAN (1-239): 5.84e-67: 209: 61.09		SCFD1_HUMAN (18-553): 2.28e-141: 425: 20.10
+	Sc
		758048 TLG1_YEAST (2-238): 4.64e-31: 116: 16.46		VPS45_YEAST (1-549): 3.04e-152: 451: 36.33
+	Hs
		1261668 STX8_HUMAN (3-236): 1.15e-36: 131: 17.45		SCFD1_HUMAN (18-553): 2.28e-141: 425: 20.10
+	Hs
		212997 STX6_HUMAN (1-239): 4.31e-68: 212: 100.00		VP33B_HUMAN (3-550): 1.22e-106: 334: 14.66
+	Hs
		169556 BET1_HUMAN (138-255): 1.8e-33: 119: 16.95		SCFD1_HUMAN (18-553): 2.28e-141: 425: 20.10
+	Dm
		1096658 Q9VV76_DROME (32-241): 4.95e-26: 103: 14.29		SLY1_DROME (1-556): 1.77e-145: 435: 20.44
+	Dm
		1096659 Q9VVX6_DROME (142-255): 8.05e-22: 89.2: 21.93		SLY1_DROME (1-556): 1.77e-145: 435: 20.44
+	Hs
		1261652 BET1L_HUMAN (155-253): 9.93e-19: 80.7: 19.00		SCFD1_HUMAN (18-553): 2.28e-141: 425: 20.10