HitPredict

Interactor 1: TLX2 (O43763)
T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)
Gene: TLX2

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Hs			1 772
+	Hs
		211839 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		974244 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		679097 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		213321 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		213323 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		211837 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		974243 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		211840 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		679096 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		679098 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		211838 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10
+	Hs
		213326 TLX2_HUMAN (1-284): 1.23e-51: 172: 100.00		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		211844 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		974247 HHEX_HUMAN (56-258): 2.11e-41: 145: 30.73		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		679101 TLX1_HUMAN (79-283): 1.33e-38: 140: 62.62		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Mm
		526708 MSX1_MOUSE (62-243): 1.01e-37: 136: 32.45		TLE5_MOUSE (1-200): 2.63e-100: 309: 61.69
+	Ce
		137693 HM24_CAEEL (56-222): 7.74e-39: 139: 33.33		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09
+	Mm
		223203 TLX3_MOUSE (6-273): 2.36e-41: 146: 57.91		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66
+	Hs
		211960 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		TBL1R_HUMAN (571-771): 3.06e-46: 174: 15.07
+	Hs
		211820 TLX3_HUMAN (6-273): 3.29e-41: 145: 57.55		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12