HitPredict

Interactor 1: KRT86 (O43790)
Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26)
Gene: KRT86

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 217
+	Hs
		444533 K2C7_HUMAN (22-461): 5.84e-160: 463: 50.91		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		380590 K2C1_HUMAN (75-431): 4.15e-124: 377: 54.44		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		409046 K2C8_HUMAN (78-443): 3.96e-117: 354: 56.83		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (1-478): 1.48e-107: 330: 92.89		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924469 KRT83_HUMAN (9-484): 1.27e-104: 322: 90.34		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924470 KRT85_HUMAN (1-476): 2.9e-96: 301: 81.78		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (2-420): 2.48e-87: 279: 48.93		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924895 KRT82_HUMAN (4-433): 2.04e-81: 263: 60.59		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		1060206 Q148Q7_MOUSE (8-420): 7.93e-79: 257: 50.79		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		531551 K2C5_HUMAN (72-420): 8.38e-71: 237: 59.26		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		359480 K2C6A_HUMAN (72-420): 1.4e-69: 233: 58.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924741 KRT35_HUMAN (4-417): 6.23e-67: 223: 26.99		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924575 K1H2_HUMAN (4-417): 1.15e-66: 222: 24.16		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280786 KRT36_HUMAN (4-417): 1.13e-64: 218: 25.78		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		1141145 Q8BIS2_MOUSE (37-420): 1.48e-61: 211: 57.29		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Mm
		403456 K2C5_MOUSE (72-420): 1.87e-69: 233: 58.97		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		442865 KRT35_HUMAN (4-417): 6.23e-67: 223: 26.99		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		280771 KRT36_HUMAN (4-417): 1.13e-64: 218: 25.78		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39