HitPredict

Interactor 1: CPSF5 (O43809)
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)
Gene: NUDT21

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NUDIX_2~RRM_1
Common GO terms	GO:0003682 - chromatin binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing and 1 others more... GO:0042382 - paraspeckles
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 471
+	Mm
		1307785 CPSF5_MOUSE (1-227): 4.31e-152: 423: 99.56		NONO_MOUSE (1-471): 4.7e-94: 294: 98.31
+	Hs
		215001 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41
+	Mm
		1246847 CPSF5_MOUSE (1-227): 4.31e-152: 423: 99.56		PSPC1_MOUSE (20-470): 5.48e-67: 225: 57.40
+	Hs
		214849 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92
+	Hs
		214942 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82