HitPredict

Interactor 1: CPSF5 (O43809)
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)
Gene: NUDT21

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16055720
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 903
+	Hs
		125027 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		214877 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		214975 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		215043 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71