HitPredict

Interactor 1: CPSF5 (O43809)
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)
Gene: NUDT21

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20972459
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016604 - nuclear body GO:0042803 - protein homodimerization activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 400
+	Hs
		214878 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		215016 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		125027 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		215043 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62
+	Hs
		214877 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		215050 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Dm
		1115152 Q9VSY2_DROME (7-184): 6.33e-106: 305: 73.55		YAP1_DROME (17-223): 5.05e-46: 164: 22.80