HitPredict

Interactor 1: CPSF5 (O43809)
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)
Gene: NUDT21

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23184937
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0030154 - cell differentiation
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 757
+	Hs
		215016 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125027 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		214877 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		214975 CPSF5_HUMAN (1-227): 4.65e-152: 423: 100.00		HUWE1_HUMAN (71-756): 0: 583: 30.14