HitPredict

Interactor 1: AKAP8 (O43823)
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)
Gene: AKAP8

Interactor 2: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	14641107, 21654808
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0042826 - histone deacetylase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 692 Hs			1 295
+	Hs
		215589 AKAP8_HUMAN (1-692): 0: 1008: 100.00		CCND2_HUMAN (3-295): 5.15e-81: 248: 61.22
+	Hs
		215590 AKAP8_HUMAN (1-692): 0: 1008: 100.00		CCND3_HUMAN (3-295): 2.73e-76: 236: 51.69
+	Mm
		629222 AKAP8_MOUSE (1-692): 0: 966: 78.36		CCND1_MOUSE (1-295): 1.76e-82: 252: 93.90
+	Cl
		47343 AKAP8_CANLF (1-692): 0: 955: 81.48		A0A8C0MF30_CANLF (3-295): 9.61e-76: 234: 51.69