HitPredict

Interactor 1: TYOBP (O43914)
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)
Gene: TYROBP

Interactor 2: CLM6 (Q08708)
CMRF35-like molecule 6 (CLM-6) (CD300 antigen-like family member C) (CMRF35-A1) (CMRF-35) (Immunoglobulin superfamily member 16) (IgSF16) (CD antigen CD300c)
Gene: CD300C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22291008
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006968 - cellular defense response
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 113 Hs			1 224
+	Mm
		222481 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		CLM4_MOUSE (1-224): 4.74e-82: 245: 48.68
+	Hs
		66493 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM7_HUMAN (8-223): 4.85e-60: 188: 31.34
+	Hs
		3044 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CD3CH_HUMAN (1-216): 4.3e-58: 184: 45.95
+	Hs
		217328 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM5_HUMAN (25-212): 4.33e-46: 153: 41.27
+	Hs
		217362 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		TREM1_HUMAN (10-199): 2.37e-40: 139: 19.12
+	Hs
		217292 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		NCTR2_HUMAN (5-183): 3.85e-39: 138: 27.32
+	Hs
		217366 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		TREM2_HUMAN (13-192): 2.36e-37: 131: 25.53
+	Mm
		222482 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		Q8BNV8_MOUSE (26-187): 9.53e-36: 127: 23.46
+	Mm
		222485 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		TREM3_MOUSE (18-116): 9.39e-25: 97.9: 22.12