HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 463
+	Mm
		1376695 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		RUVB2_MOUSE (1-463): 0: 718: 99.57
+	Hs
		1059948 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		1059951 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		1018756 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		1357684 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		RUVB1_HUMAN (8-451): 0: 655: 42.67