HitPredict

Interactor 1: ORC4 (O43929)
Origin recognition complex subunit 4
Gene: ORC4

Interactor 2: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	12614612, 15232106
Identification Methods	two hybrid, pull down, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	MCM~ORC4_C, MCM_lid~ORC4_C
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006270 - DNA replication initiation and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 436 Hs			1 808
+	Hs
		627341 CDC6_HUMAN (3-419): 4.83e-106: 326: 13.99		MCM3_HUMAN (1-808): 0: 944: 100.00
+	Hs
		217789 ORC4_HUMAN (1-436): 1.82e-141: 413: 100.00		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		217802 ORC4_HUMAN (1-436): 1.82e-141: 413: 100.00		MCM6_HUMAN (2-800): 0: 688: 26.50
+	Hs
		217779 ORC4_HUMAN (1-436): 1.82e-141: 413: 100.00		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		217780 ORC4_HUMAN (1-436): 1.82e-141: 413: 100.00		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		832428 ORC1_HUMAN (6-417): 2.28e-106: 335: 17.07		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		832668 CDC6_HUMAN (3-419): 4.83e-106: 326: 13.99		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		1033381 ORC1_HUMAN (6-417): 2.28e-106: 335: 17.07		MCM6_HUMAN (2-800): 0: 688: 26.50
+	Hs
		708627 ORC1_HUMAN (6-417): 2.28e-106: 335: 17.07		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		708744 CDC6_HUMAN (3-419): 4.83e-106: 326: 13.99		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		708434 ORC1_HUMAN (6-417): 2.28e-106: 335: 17.07		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		708888 ORC1_HUMAN (6-417): 2.28e-106: 335: 17.07		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		709020 CDC6_HUMAN (3-419): 4.83e-106: 326: 13.99		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Sc
		667613 ORC1_YEAST (15-421): 6.53e-72: 245: 12.21		MCM2_YEAST (6-668): 0: 664: 32.15
+	Sc
		447785 CDC6_YEAST (2-420): 5.1e-74: 242: 11.39		MCM2_YEAST (6-668): 0: 664: 32.15
+	Sc
		622184 ORC1_YEAST (15-421): 6.53e-72: 245: 12.21		MCM3_YEAST (45-782): 0: 655: 44.49
+	Sc
		675544 ORC1_YEAST (15-421): 6.53e-72: 245: 12.21		MCM4_YEAST (9-804): 0: 654: 27.82
+	Sc
		447782 CDC6_YEAST (2-420): 5.1e-74: 242: 11.39		MCM3_YEAST (45-782): 0: 655: 44.49
+	Sc
		744785 ORC1_YEAST (15-421): 6.53e-72: 245: 12.21		MCM7_YEAST (20-674): 8.95e-91: 305: 34.27
+	Sc
		667877 ORC1_YEAST (15-421): 6.53e-72: 245: 12.21		MCM5_YEAST (8-650): 1.72e-86: 292: 31.51