HitPredict

Interactor 1: ORC4 (O43929)
Origin recognition complex subunit 4
Gene: ORC4

Interactor 2: ORC1 (Q13415)
Origin recognition complex subunit 1 (Replication control protein 1)
Gene: ORC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.921

The method score is based on:

Property Details
Experiments 12614612, 26496610, 31160578, 16549788, 17716973
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA_16, AAA_16~AAA_lid_10, AAA~ORC4_C, AAA_lid_10~ORC4_C, Cdc6_C~ORC4_C
Common GO terms GO:0000781 - chromosome, telomeric region
GO:0000808 - origin recognition complex
GO:0003688 - DNA replication origin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 5 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 436
Hs

1 861
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Last updated: 15 Jul 2024