HitPredict

Interactor 1: ORC4 (O43929)
Origin recognition complex subunit 4
Gene: ORC4

Interactor 2: ORC6 (Q9Y5N6)
Origin recognition complex subunit 6
Gene: ORC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	12614612, 15910003, 15232106, 18234858
Identification Methods	two hybrid, affinity chromatography technology, pull down, bimolecular fluorescence complementation, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000808 - origin recognition complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005664 - nuclear origin of replication recognition complex GO:0005829 - cytosol and 1 others more... GO:0006270 - DNA replication initiation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 436 Hs			1 252
+	Hs
		1306132 CDC6_HUMAN (3-419): 4.83e-106: 326: 13.99		ORC6_HUMAN (1-252): 7.09e-123: 351: 100.00
+	Dm
		184173 ORC1_DROME (1-416): 9.41e-107: 338: 15.71		ORC6_DROME (3-248): 7.17e-94: 278: 27.82
+	Dm
		1376237 Q9W102_DROME (13-433): 1.46e-98: 304: 41.83		ORC6_DROME (3-248): 7.17e-94: 278: 27.82
+	At
		1352830 ORC1B_ARATH (19-422): 4.07e-116: 360: 15.89		ORC6_ARATH (6-245): 1.81e-66: 209: 25.30
+	Dm
		1373671 Q9VSM9_DROME (2-419): 5.11e-81: 264: 15.07		ORC6_DROME (3-248): 7.17e-94: 278: 27.82
+	At
		1150972 ORC4_ARATH (18-423): 3.35e-97: 299: 28.85		ORC6_ARATH (6-245): 1.81e-66: 209: 25.30